Stoke City FC Women spelar i Northern Premier Division North, vilket är den tredje högsta ligan i England.
Laget spelar sina hemmamatcher på Emerys Stadium, Norton Uniteds gamla plan i Smallthorne i utkanten av Burslem. Adressen dit är Community Drive, ST6 1QF. De flesta matcherna går av stapeln på söndagar, kl 14.00.
Länk till serietabellen: Northern Premier Division North
| Datum | Match | Resultat | Turnering |
| 2021-08-22 | STOKE CITY FC – Fylde Ladies | 2-3 | Northern Premier Division |
| 2021-08-26 | STOKE CITY FC – Derby County Ladies | 2-3 | Northern Premier Division |
| 2021-08-29 | Sheffield FC Ladies – STOKE CITY FC | 1-0 | Northern Premier Division |
| 2021-09-05 | Loughborough Lightning Women – STOKE CITY FC | 1-5 | Northern Premier Division |
| 2021-09-12 | STOKE CITY FC – Solihull Moors | 7-0 | Ligacupen |
| 2021-09-26 | STOKE CITY FC – Brighouse Town Ladies | 1-1 | Northern Premier Division |
| 2021-10-03 | Huddersfield Town Women – STOKE CITY FC | 5-1 | Northern Premier Division |
| 2021-10-05 | STOKE CITY FC – Wolves Ladies | 0-4 | Northern Premier Division |
| 2021-10-10 | Brighouse Town Ladies – STOKE CITY FC | 5-2 | Ligacupen |
| 2021-10-17 | Middlesbrough Ladies – STOKE CITY FC | 1-2 | Northern Premier Division |
| 2021-10-24 | Hull City Ladies – STOKE CITY FC | 1-4 | Northern Premier Division |
| 2021-11-07 | STOKE CITY FC – Burnley Women | 0-2 | Northern Premier Division |
| 2021-11-14 | STOKE CITY FC – Doncaster Rovers Belles | 5-3 | FA-cupen |
| 2021-11-21 | STOKE CITY FC – City of Stoke FC | 8-0 | County Cup |
| 2021-12-05 | STOKE CITY FC – Norwich City | 5-1 | FA-cupen |
| 2021-12-12 | STOKE CITY FC – Nottingham Forest Ladies | 1-2 | FA-cupen |
| 2022-01-09 | West Bromwich Albion WFC – STOKE CITY FC | 1-0 | Northern Premier Division |
| 2022-01-16 | Stoke City FC Reserves – STOKE CITY FC | 0-3 | Staffordshire Challenge Cup |
| 2022-01-23 | STOKE CITY FC – Nottingham Forest Ladies | 0-1 | Northern Premier Division |
| 2022-01-26 | Derby County Ladies – STOKE CITY FC | 5-0 | Northern Premier Division |
| 2022-01-30 | STOKE CITY FC – Sheffield FC Ladies | 2-1 | Northern Premier Division |
| 2022-02-13 | Brighouse Town Ladies – STOKE CITY FC | 2-3 | Northern Premier Division |
| 2022-02-20 | Sporting Khalsa Women – STOKE CITY FC | 0-1 e förl | Staffordshire Challenge Cup |
| 2022-02-27 | STOKE CITY FC – Huddersfield Town Women | 1-2 | Northern Premier Division |
| 2022-03-02 | Wolves Ladies – STOKE CITY FC | 5-0 | Northern Premier Division |
| 2022-03-06 | STOKE CITY FC – Middlesbrough Ladies | 2-6 | Northern Premier Division |
| 2022-03-13 | Nottingham Forest Ladies – STOKE CITY FC | 2-0 | Northern Premier Division |
| 2022-03-27 | Burnley Women – STOKE CITY FC | 3-1 | Northern Premier Division |
| 2022-04-03 | STOKE CITY FC – Loughborough Lightning Women | 4-2 | Northern Premier Division |
| 2022-04-10 | Fylde Ladies – STOKE CITY FC | 2-1 | Northern Premier Division |
| 2022-04-12 | STOKE CITY FC – Leek Town Ladies | 10-0 | Staffordshire Challenge Cup, final |
| 2022-04-24 | STOKE CITY FC – Hull City Ladies | 3-0 | Northern Premier Division |
| 2022-05-01 | STOKE CITY FC – West Bromwich Albion WFC | 2-0 | Northern Premier Division |